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Sep 18, 2014
Wagnon JL, Korn MJ, Parent R, Tarpey TA, Jones JM, Hammer MF, Murphy GG, Parent JM, Meisler MH
De novo mutations of the voltage-gated sodium channel gene SCN8A have recently been recognized as a cause of epileptic encephalopathy, which is characterized by refractory seizures with developmental delay and cognitiv...
Sep 18, 2014
French JA, Baroldi P, Brittain ST, Johnson JK, PROSPER Investigators Study Group
OBJECTIVE: To evaluate the efficacy, tolerability, and safety of once-daily 1200 mg and 2400 mg SPN-804 (Oxtellar XR™, Supernus Pharmaceuticals), an extended-release tablet formulation of oxcarbazepine (OXC), added to ...
Sep 17, 2014
Borlot F, Wither RG, Ali A, Wu N, Verocai F, Andrade DM
RATIONALE: Given verapamil's property as a glycoprotein inhibitor, this drug could increase the effective concentration of antiepileptic drugs (AEDs) in the epileptic foci, reducing the number of seizures. This pilot s...
Sep 15, 2014
Illingworth JL, Watson P, Ring H
Seizure precipitants are commonly reported in the general population of people with epilepsy. However, there has been little research in this area in people with epilepsy and intellectual disability (ID). We conducted ...
Sep 13, 2014
Parazzini M, Fiocchi S, Liorni I, Priori A, Ravazzani P
Transcranial direct current stimulation (tDCS) was recently proposed for the treatment of epilepsy. However, the electrode arrangement for this case is debated. This paper analyzes the influence of the position of the ...
Sep 13, 2014
Buffel I, Meurs A, Raedt R, de Herdt V, Decorte L, Bertier L, Delbeke J, Wadman W, Vonck K, Boon P
Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold...
Sep 12, 2014
Gillespie AI, Helou LB, Ingle JW, Baldwin M, Rosen CA
Vagal nerve stimulators (VNS) are implanted to treat medically refractory epilepsy and depression. The VNS stimulates the vagus nerve in the left neck. Laryngeal side effects are common and include dysphagia, dysphonia...
Sep 11, 2014
Prasad M, Krishnan PR, Sequeira R, Al-Roomi K
BACKGROUND: Status epilepticus is a medical emergency associated with significant mortality and morbidity that requires immediate and effective treatment. OBJECTIVES: (1) To determine whether a particular antic...
Sep 11, 2014
Prager EM, Figueiredo TH, Long RP, Aroniadou-Anderjaska V, Apland JP, Braga MF
Without timely pharmacological treatment, nerve agent exposure can cause a large number of casualties, as occurred in the recent sarin attack in Syria. Nerve agent-induced seizures are initiated due to inhibition of ac...
Sep 10, 2014
Khetarpal M, Yadav M, Kulkarni D, Gopinath R
A 63-year-old man with severe Parkinson's disease (PD) who had been implanted with deep brain stimulators into both sides underwent radical nephrectomy under general anaesthesia with standard monitoring. Deep brain sti...