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May 25, 2015
Lesca G, Depienne C
Epilepsies have long remained refractory to gene identification due to several obstacles, including a highly variable inter- and intrafamilial expressivity of the phenotypes, a high frequency of phenocopies, and a huge...
May 23, 2015
Arcos A, Romero L, Gelabert M, Prieto A, Pardo J, Osorio XR, Arráez MA
Despite the introduction of new antiepileptic drugs and advances in the surgical treatment of epilepsy, an important group of patients still remains uncontrolled by any of these methods. The relatively recent introduct...
May 23, 2015
Oner AY, Eryurt B, Ucar M, Capraz I, Kurt G, Bilir E, Tali T
BACKGROUND: Accurate lateralization of the epileptogenic focus in temporal lobe epilepsy (TLE) is crucial. Pulsed arterial spin labeling (pASL) has the capability of quantifying local relative cerebral blood flow (rCBF...
May 23, 2015
Bandarabadi M, Rasekhi J, Teixeira CA, Netoff TI, Parhi KK, Dourado A
A novel approach using neuronal potential similarity (NPS) of two intracranial electroencephalogram (iEEG) electrodes placed over the foci is proposed for automated early seizure detection in patients with refractory p...
May 23, 2015
Živković S
Intravenous immunoglobulins (IVIGs) are often used in the treatment of autoimmune disorders and immunodeficiencies, and it has been estimated that neurologic indications can account for up to 43% of IVIG used in clinic...
May 21, 2015
Martlé V, Raedt R, Waelbers T, Smolders I, Vonck K, Boon P, Van Ham L, Duchateau L, Bhatti S
BACKGROUND: Vagus nerve stimulation (VNS) is an established treatment for refractory epilepsy in humans, but the precise mechanism of action (MOA), predictive responsive factors and the optimal stimulation parameters r...
May 21, 2015
Freitas-Lima P, Monteiro EA, Macedo LR, Funayama SS, Ferreira FI, Matias Júnior I, Angelis G, Nogueira AM, Alexandre V, Velasco TR, Pinheiro-Martins AP, Sakamoto AC
Objective Characterize the social profile and the need of information from patients with refractory epilepsy. Method A semi-structured questionnaire was applied to 103 patients to investigate sociodemographic aspects, ...
May 20, 2015
Davoren JE, Claffey MM, Snow SL, Reese MR, Arora G, Butler CR, Boscoe BP, Chenard L, DeNinno SL, Drozda SE, Duplantier AJ, Moine L, Rogers BN, Rong S, Schuyten K, Wright AS, Zhang L, Serpa KA, Weber ML, Stolyar P, Whisman TL, Baker K, Tse K, Clark AJ, Rong H, Mather RJ, Lowe JA
Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort...
May 16, 2015
Taussig D, Dorfmüller G, Save J, Fohlen M, Chipaux M, Ferrand-Sorbets S, Delalande O, Bulteau C
BACKGROUND: Infantile spasms (IS) are a severe epileptic encephalopathy. In patients with early focal ischemia and refractory IS, a preoperative evaluation is required even if IS are the only ictal manifestation. ...
May 16, 2015
Bakker DP, Catsman-Berrevoets CE, Neuteboom RF
BACKGROUND: Many different corticosteroid treatment schedules have been used in order to treat refractory epileptic seizures with encouraging effects on seizure reduction in many epileptic syndromes. OBJECTIVE:...