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Mar 31, 2015
Gess JL, Denham M, Pennell PB, Gross RE, Stringer AY
Dysnomia is associated with temporal lobe epilepsy and may include a deficit in recalling the names of familiar people. The deficit can worsen following surgery to relieve refractory seizures. The following is a case r...
Mar 31, 2015
Martinkovic L, Hecimovic H, Sulc V, Marecek R, Marusic P
A clear concept of epileptic zones remains of high clinical relevance in presurgical evaluation of refractory epilepsy patients and in resection planning. Recent advances in understanding how each of the epileptic zone...
Mar 31, 2015
Reid AY, Staba RJ
Limbic epilepsy refers to a condition that consists of epileptic seizures that originate in or preferentially involve the limbic system. The majority of cases are medically refractory, necessitating surgical resection ...
Mar 31, 2015
Behr C, D'Antuono M, Hamidi S, Herrington R, Lévesque M, Salami P, Shiri Z, Köhling R, Avoli M
In this review, we summarize findings obtained in acute and chronic epilepsy models and in particular experiments that have revealed how neuronal networks in the limbic system-which is closely involved in the pathophys...
Mar 31, 2015
Mogul DJ, van Drongelen W
Epilepsy afflicts approximately 1-2% of the world's population. The mainstay therapy for treating the chronic recurrent seizures that are emblematic of epilepsy are drugs that manipulate levels of neuronal excitability...
Mar 31, 2015
Kong ST, Ho CS, Ho PC, Lim SH
PURPOSE: To determine the proportion of population of adult people with epilepsy (PWE) in Singapore, who suffer from drug resistant epilepsy (DRE). METHODS: All adult PWE who had attended the neurology speciali...
Mar 31, 2015
Velizarova R, Crespel A, Genton P, Serafini A, Gelisse P
PURPOSE: To examine the clinical effect of zonisamide (ZNS) in patients with drug-resistant juvenile absence epilepsy (JAE). METHODS: Between 2006 and 2010, 13 JAE patients were successively treated with add-on...
Mar 31, 2015
D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT
Acute treatment with positive allosteric modulators (PAMs) of mGlu1 and mGlu5 metabotropic glutamate receptors (RO0711401 and VU0360172, respectively) reduces the incidence of spike-and wave discharges in the WAG/Rij r...
Mar 31, 2015
Li Y, Chen J, Zeng T, Lei D, Chen L, Zhou D
Hypoxia-inducible factor-1α (HIF-1α) is thought to mediate pharmacoresistance in tumor by inducing Pgp overexpression. We aimed to investigate the expression of HIF-1α and MDR1/P-glycoprotein in refractory epilepsy, to...
Mar 31, 2015
Mateo-Carrasco H, Serrano-Castro PJ, Molina-Cuadrado E, Goodwin M, Nguyen TV, Kotecha PN
Case We discuss the case of a 5-year-old long-standing epileptic woman, who received oxcarbazepine 2.1 g/day, and levetiracetam 3 g/day (started in 2005 and up-titrated according to response). In October/2008, due to p...

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