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Aug 30, 2014
Faulkner MA
PURPOSE: The pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of perampanel are reviewed. SUMMARY: Perampanel, a first-in-class antiepileptic agent, was recently approved for use as adjunc...
Aug 29, 2014
Ozelo HF, Alessio A, Sercheli MS, Bilevicius E, Pedro T, Pereira FR, Rondina JM, Damasceno BP, Cendes F, Covolan RJ
BACKGROUND: It is known that the abnormal neural activity in epilepsy may be associated to the reorganization of neural circuits and brain plasticity in various ways. On that basis, we hypothesized that changes in neur...
Aug 29, 2014
Dulin JD, Noreika DM, Coyne PJ
ABSTRACT No consensus guidelines exist for the treatment of refractory myoclonic status epilepticus or refractory myoclonus in the palliative care setting. Evidence-based guidelines for the general medical population a...
Aug 29, 2014
Clancy JA, Mary DA, Witte KK, Greenwood JP, Deuchars SA, Deuchars J
BACKGROUND: Vagus nerve stimulation (VNS) is currently used to treat refractory epilepsy and is being investigated as a potential therapy for a range of conditions, including heart failure, tinnitus, obesity and Alzhei...
Aug 27, 2014
Mora G, Rendón I
A subgroup of patients with epilepsy die suddenly and ictal bradycardia (IB) has been implicated. We describe a 63-year-old man with diagnosis of refractory epilepsy. The patient had long video and EEG/ECG recordings (...
Aug 27, 2014
Goldberger ZD, Creutzfeldt CJ, Goldberger AL
Cerebrogenic ECG abnormalities, especially prominent T wave inversions and prolongation of the QT(U) interval, are well-described. Brady- and tachyarrhythmias, including polymorphic VT, have been also described in the ...
Aug 26, 2014
Press C, Wallace A, Chapman KE
Rasmussen encephalitis (RE) is an inflammatory unilateral progressive medically refractory epilepsy associated with hemiparesis, cognitive dysfunction, and hemispheric atrophy. Here, we present 2 cases from our institu...
Aug 26, 2014
Serletis D, Bulacio J, Bingaman W, Najm I, González-Martínez J
Object Stereoelectroencephalography (SEEG) is a methodology that permits accurate 3D in vivo electroclinical recordings of epileptiform activity. Among other general indications for invasive intracranial electroencepha...
Aug 26, 2014
Lamberts RJ, Tan HL, Leijten QH, Sander JW, Thijs RD
Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Patients with refractory epilepsy are at especially high risk of SUDEP. SUDEP occurs predominantly at night and ...
Aug 26, 2014
Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS
Infantile spasms are seizures manifesting in infantile epileptic encephalopathies that are associated with poor epilepsy and cognitive outcomes. The current therapies are not always effective or are associated with ser...

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