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May 26, 2016
Pickrell WO, Smith PE
Treatment resistance affects around 20% of people with epilepsy and carries a significant comorbidity. It is important to ensure that the diagnosis of epilepsy is secure and the underlying cause of the epilepsy is inve...
May 24, 2016
Lambrechts DA, de Kinderen RJ, Vles HS, de Louw AJ, Aldenkamp AP, Majoie MJ
The present study assessed the long-term (i.e., 24months) efficacy of the ketogenic diet (KD) as an add-on therapy in children with refractory epilepsy, with focus on seizure frequency, seizure severity, and tolerabili...
May 24, 2016
Vehmeijer FO, van der Louw EJ, Arts WF, Catsman-Berrevoets CE, Neuteboom RF
BACKGROUND: The ketogenic diet (KD) can be effective in reducing seizures in children. Predictors of success have not been identified yet. AIMS: To evaluate efficacy of KD treatment and to search for child- or ...
May 24, 2016
Mahajnah M, Corderio D, Austin V, Herd S, Mutch C, Carter M, Struys E, Mercimek-Mahmutoglu S
BACKGROUND: Pyridoxine-dependent epilepsy (PDE) is caused by mutations in ALDH7A1 (PDE-ALDH7A1), which encodes α-aminoadipic semialdehyde dehydrogenase in the lysine catabolic pathway, resulting in accumulation of α-am...
May 22, 2016
Matsuda KM, Sharma D, Schonfeld AR, Kwatra SG
Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative ther...
May 21, 2016
IJff DM, Postulart D, Lambrechts DA, Majoie MH, de Kinderen RJ, Hendriksen JG, Evers SM, Aldenkamp AP
PURPOSE: The ketogenic diet (KD) is increasingly used for the treatment of refractory epilepsy in childhood because of the beneficial effect on seizure reduction. The aim of the current study was to objectively assess ...
May 19, 2016
Doksöz Ö, Çeleğen K, Güzel O, Yılmaz Ü, Uysal U, İşgüder R, Çeleğen M, Meşe T
OBJECTIVE: Our primary aim was to determine the short-term effects of a ketogenic diet on cardiac ventricular function in patients with refractory epilepsy. METHODS: Thirty-eight drug-resistant epileptic patien...
May 19, 2016
Almuqbil M, Go C, Nagy LL, Pai N, Mamak E, Mercimek-Mahmutoglu S
OBJECTIVE: Glucose transporter 1 deficiency syndrome is an autosomal, dominantly inherited neurometabolic disorder caused by mutations in the SLC2A1 gene. Decreased glucose transport into the brain results in seizures ...
May 14, 2016
Gulati P, Cannell P, Ghia T, Bint L, Walsh P, Ghosh S, Nagarajan L
AIMS: Lacosamide (LCM) is a novel anti-epileptic drug (AED) that enhances the slow inactivation of voltage-gated sodium channels. Its efficacy as adjunctive therapy for focal seizures is confirmed in adult placebo cont...
May 13, 2016
Wang TT, Zhou D
Focal cortical dysplasia (FCD) presents a strong clinical challenge especially for the treatment of the associated epilepsy. Epilepsy in FCD is often treatment-resistant and constitutes 50% of treatment-resistant cases...

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