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Sep 2, 2014
Masino SA, Kawamura M, Ruskin DN
Adenosine receptors are a powerful therapeutic target for regulating epileptic seizures. As a homeostatic bioenergetic network regulator, adenosine is perfectly suited to establish or restore an ongoing balance between...
Aug 30, 2014
Walker MC, Williams RS
Drug-resistant epilepsy has remained a problem since the inception of antiepileptic drug development, despite the large variety of antiepileptic drugs available today. Moreover, the mechanism-of-action of these drugs i...
Aug 30, 2014
Kawamura M, Ruskin DN, Geiger JD, Boison D, Masino SA
A high-fat, low-carbohydrate ketogenic diet is an effective treatment for refractory epilepsy, yet myriad metabolic effects in vivo have not been reconciled clearly with neuronal effects. A ketogenic diet limits blood ...
Aug 30, 2014
Borlot F, Tellez-Zenteno JF, Allen A, Ali A, Snead OC, Andrade DM
OBJECTIVES: Children with severe chronic epilepsy are living longer, and they eventually transition to the adult health care system. Additional research is required to better define the population that is being transfe...
Aug 29, 2014
O'Connor SE, Richardson C, Trescher WH, Byler DL, Sather JD, Michael EH, Urbanik KB, Richards JL, Davis R, Zupanc ML, Zupec-Kania B
BACKGROUND: Refractory status epilepticus carries a high risk of morbidity and mortality for children. Traditional treatment of status epilepticus consists of multiple anticonvulsant drugs and, if needed, induction of ...
Aug 29, 2014
Bansal S, Cramp L, Blalock D, Zelleke T, Carpenter J, Kao A
BACKGROUND: Inpatient initiation of the ketogenic diet has historically involved fasting followed by gradual advancement of calories and/or diet ratio. Complications during this initiation period are common. We sought ...
Aug 28, 2014
Gipson TT, Gerner G, Srivastava S, Poretti A, Vaurio R, Hartman A, Johnston MV
BACKGROUND: Infants born with tuberous sclerosis complex, a genetic condition resulting from a mutation in TSC1 or TSC2, are at increased risk for intellectual disability and/or autism. Features of epilepsy, neuropatho...
Aug 27, 2014
Streijger F, Plunet WT, Lee JH, Liu J, Lam CK, Park S, Hilton BJ, Fransen BL, Matheson KA, Assinck P, Kwon BK, Tetzlaff W
High fat, low carbohydrate ketogenic diets (KD) are validated non-pharmacological treatments for some forms of drug-resistant epilepsy. Ketones reduce neuronal excitation and promote neuroprotection. Here, we investiga...
Aug 27, 2014
Armeno M, Caraballo R, Vaccarezza M, Alberti MJ, Rios V, Galicchio S, de Grandis ES, Mestre G, Escobal N, Matarrese P, Viollaz R, Agostinho A, Diez C, Cresta A, Cabrera A, Blanco V, Ferrero H, Gambarini V, Sosa P, Bouquet C, Caramuta L, Guisande S, Gamboni B, Hassan A, Pesce L, Argumedo L, Dlugoszewski C, DeMartini MG, Panico L
INTRODUCTION. Epilepsy is a chronic disease with onset in infancy affecting 0.5-1% of the population. One third of the patients is refractory to antiepileptic drugs and they pose a challenge for the health care team. T...
Aug 26, 2014
Schoeler NE, MacDonald L, Champion H, Helen Cross J, Sander JW, Sisodiya SM, Horne R
We aimed to assess and quantify parental beliefs regarding ketogenic dietary therapies (KDTs). We also aimed to determine whether beliefs were related to response to KDTs. Adapted versions of the Beliefs about Medicine...