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Aug 2, 2015
Tincheva S, Todorov T, Todorova A, Georgieva R, Stamatov D, Yordanova I, Kadiyska T, Georgieva B, Bojidarova M, Tacheva G, Litvinenko I, Mitev V
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants. The seizures cannot be controlled with antiepileptic medications but respond bot...
Jul 30, 2015
Rho JM
The high-fat ketogenic diet (KD) is a remarkably effective treatment for medically intractable epilepsy and has been part of the clinical armamentarium for nearly a century. However, the mechanisms underlying the KD's ...
Jul 29, 2015
Almuqbil M, Go C, Nagy LL, Pai N, Mamak E, Mercimek-Mahmutoglu S
OBJECTIVE: Glucose transporter 1 deficiency syndrome is an autosomal, dominantly inherited neurometabolic disorder caused by mutations in the SLC2A1 gene. Decreased glucose transport into the brain results in seizures ...
Jul 29, 2015
Cho CH
Jul 28, 2015
Pall ML, Levine S
The transcription factor Nrf2, nuclear factor erythroid-2-related factor 2, activates the transcription of over 500 genes in the human genome, most of which have cytoprotective functions. Nrf2 produces cytoprotection b...
Jul 25, 2015
Vehmeijer FO, van der Louw EJ, Arts WF, Catsman-Berrevoets CE, Neuteboom RF
BACKGROUND: The ketogenic diet (KD) can be effective in reducing seizures in children. Predictors of success have not been identified yet. AIMS: To evaluate efficacy of KD treatment and to search for child- or ...
Jul 25, 2015
Jaggumantri S, Dunbar M, Edgar V, Mignone C, Newlove T, Elango R, Collet JP, Sargent M, Stockler-Ipsiroglu S, van Karnebeek CD
BACKGROUND: Creatine transporter (SLC6A8) deficiency is an X-linked inborn error of metabolism characterized by cerebral creatine deficiency, behavioral problems, seizures, hypotonia, and intellectual developmental dis...
Jul 23, 2015
Felton EA, Cervenka MC
Ketogenic diet therapies for epilepsy have been described since the fifth century and published in scientific literature since the early 1900s. Since that time, the diet's popularity has waxed and waned as newer drugs ...
Jul 23, 2015
Vaccarezza MM, Silva WH
The ketogenic diet (KD) is currently a well-established treatment for patients with medically refractory, nonsurgical epilepsy. However, despite its efficacy, the KD is highly restrictive and constitutes a treatment wi...
Jul 23, 2015
Tasker RC, Vitali SH
PURPOSE OF REVIEW: To discuss the use of continuous infusions, general anesthesia, hypothermia, and ketogenic diet as treatment for uncontrolled status epilepticus in pediatric patients. RECENT FINDINGS: Recent...