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Jul 26, 2014
Correia FD, Freitas J, Magalhães R, Lopes J, Ramalheira J, Lopes-Lima J, Chaves J
PURPOSE: Eslicarbazepine acetate (ESL) is a new generation voltage-gated sodium channel blocker. It has completed one phase II clinical trial and three phase III clinical trials, two of which with 1-year open label ext...
Jul 25, 2014
Franco V, Canevini MP, Capovilla G, De Sarro G, Galimberti CA, Gatti G, Guerrini R, La Neve A, Rosati E, Specchio LM, Striano S, Tinuper P, Perucca E
PURPOSE: To assess the extent of off-label prescribing of antiepileptic drugs (AEDs) and associated variables in a large population of patients with pharmacoresistant epilepsy. METHODS: Descriptive analysis of ...
Jul 24, 2014
Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L
INTRODUCTION: This review provides a synopsis for clinicians on the use of antiepileptic drugs (AEDs) in the breastfeeding mother. METHODS: For each AED, we collected all retrievable data from Hale's "Medicatio...
Jul 22, 2014
Zhang MY, Zheng CY, Zou MM, Zhu JW, Zhang Y, Wang J, Liu CF, Li QF, Xiao ZC, Li S, Ma QH, Xu RX
Hyperactivity and its compensatory mechanisms may causally contribute to synaptic and cognitive deficits in Alzheimer's disease (AD). Blocking the overexcitation of the neural network, with levetiracetam (LEV), a sodiu...
Jul 22, 2014
Voltzenlogel V, Vignal JP, Hirsch E, Manning L
PURPOSE: Seizure frequency, although considered as an important factor in memory impairment in mesial temporal epilepsy (mTLE), is mostly confounded with other clinical variables, making it unclear to what extent recur...
Jul 22, 2014
Bolin K, Berggren F, Landtblom AM
OBJECTIVE: To estimate the regional differences in the prevalence of epilepsy and the associated costs due to inpatient and outpatient care and anti-epileptic drug (AED) utilization for the years 2005 and 2011 in Swede...
Jul 22, 2014
Caraballo R, Pasteris MC, Fortini PS, Portuondo E
PURPOSE: We present six patients with epilepsy of infancy with migrating focal seizures (EIMFS) and provide a comprehensive evaluation of potassium bromide therapy. METHOD: Between February 1, 2007 and July 31,...
Jul 22, 2014
Esaian D, Joset D, Lazarovits C, Dugan PC, Fridman D
OBJECTIVE: Refractory status epilepticus (RSE) requires aggressive management with multiple antiepileptic drugs (AEDs) often requiring the initiation of continuous infusions of propofol, midazolam, or pentobarbital to ...
Jul 18, 2014
Contin M, Albani F, Riva R, Candela C, Mohamed S, Baruzzi A
BACKGROUND: Lacosamide (LCM) is one of the newer antiepileptic drugs (AEDs) licensed as add-on treatment for partial epilepsy. Data on LCM pharmacokinetics and interactions are limited and partly contradictory. The pur...
Jul 16, 2014
Nelson M
BACKGROUND: Epilepsy is a common neurological disease in pregnancy. There is an increased risk of teratogenesis in pregnant women taking antiepileptic drugs (AEDs). Stopping medication can result in seizures, potential...