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Jul 25, 2016
Ossemann M, de Fays K, Bihin B, Vandermeeren Y
BACKGROUND: Antiepileptic drugs (AEDs) decrease the occurrence of epileptic seizures and modulate cortical excitability through several mechanisms that likely interact. The modulation of brain excitability by AEDs is b...
Jul 22, 2016
Price M, Günther A, Kwan JS
BACKGROUND: Intracranial venous thrombosis (ICVT) commonly presents with seizures in the acute period, and some people may develop recurrent seizures in the long term. The prophylactic use of antiepileptic drugs (AEDs)...
Jul 21, 2016
Steinhoff BJ, Bacher M, Kurth C, Staack AM, Kornmeier R
Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated...
Jul 20, 2016
Voll A, Hernández-Ronquillo L, Buckley S, Téllez-Zenteno JF
OBJECTIVES: Using an adult cohort of patients with generalized epilepsy, we aimed to identify risk factors for development of drug-resistant epilepsy (DRE), which if identifiable would allow patients to receive earlier...
Jul 20, 2016
Kakooza-Mwesige A
Epilepsy is one of the most common neurological conditions worldwide, with many affected persons found in Asia, Latin America, and sub-Saharan Africa. Relatedly, the large majority found in these regions does not recei...
Jul 17, 2016
Elger CE, Rademacher M, Brandt C, Elmoufti S, Dedeken P, Eckhardt K, Tennigkeit F, De Backer M
Treatment with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine (CBZ) can lead to changes in reproductive, endocrine, and lipid parameters, resulting in clinical symptoms for some patients. Previous stu...
Jul 16, 2016
Pontes JC, Lima TZ, Queiroz CM, Cinini SM, Blanco MM, Mello LE
The efficiency of most of the new antiepileptic drugs (AEDs) on clinical trials still falls short the success reported in pre-clinical studies, possibly because the validity of the animal models is insufficient to full...
Jul 15, 2016
Lee JH, Kim SE, Park CH, Yoo JH, Lee HW
Epilepsy patients often have cognitive dysfunction even at early stages of disease. We investigated the relationship between structural findings and neuropsychological status in drug-naïve newly diagnosed pediatric epi...
Jul 15, 2016
Avaliani N, Andersson M, Runegaard AH, Woldbye D, Kokaia M
Epilepsy is a neurological disorder with a prevalence of ≈1% of general population. Available antiepileptic drugs (AEDs) have multiple side effects and are ineffective in 30% of patients. Therefore, development of effe...
Jul 15, 2016
Baftiu A, Johannessen Landmark C, Rusten IR, Feet SA, Johannessen SI, Larsson PG
PURPOSE: The purpose of this study was to investigate changes in utilisation of antiepileptic drugs (AEDs) in epilepsy and non-epilepsy disorders in Norway and furthermore to study the retention rates of the most commo...

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