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Dec 7, 2016
Nolan SJ, Sudell M, Tudur Smith C, Marson AG
BACKGROUND: Epilepsy is a common neurological condition in which abnormal electrical discharges from the brain cause recurrent unprovoked seizures. It is believed that with effective drug treatment, up to 70% of indivi...
Dec 7, 2016
Kasteleijn-Nolst Trenité DG
Development of new effective medicines for patients, who continue to have seizures or experience unwanted side-effects, is an important goal. The human "Photosensitivity Model", a POC study, helps to achieve this goal ...
Dec 7, 2016
Cahill V, McCorry D, Soryal I, Rajabally YA
OBJECTIVE: Whether new antiepileptic drugs (AEDs) may result in neuropathy is unknown but possible given their effects on vitamin metabolism. This analysis aimed to determine frequency and correlates of neuropathy in s...
Dec 6, 2016
Bauquier SH, McLean KJ, Jiang JL, Boston RC, Lai A, Yue Z, Moulton SE, Halliday AJ, Wallace G, Cook MJ
This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti-epileptic drugs (AEDs). Three by three mi...
Dec 2, 2016
Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K
CLINICAL CHARACTERISTICS: STXBP1 encephalopathy with epilepsy is characterized by early-onset encephalopathy with epilepsy (i.e., moderate to severe intellectual disability, refractory seizures, and ongoing epileptifor...
Dec 2, 2016
Franzin A, Panni P, Spatola G, Vecchio AD, Gallotti AL, Gigliotti CR, Cavalli A, Donofrio CA, Mortini P
OBJECTIVE There are few reported series regarding volume-staged Gamma Knife radiosurgery (GKRS) for the treatment of large, complex, cerebral arteriovenous malformations (AVMs). The object of this study was to report t...
Dec 2, 2016
Colic S, Wither RG, Lang M, Zhang L, Eubanks JH, Bardakjian BL
OBJECTIVE: Antiepileptic drug (AED) treatments produce inconsistent outcomes, often necessitating patients to go through several drug trials until a successful treatment can be found. This study proposes the use of mac...
Nov 28, 2016
AlQassmi A, Burneo JG, McLachlan RS, Mirsattari SM
OBJECTIVE: We present a single-center retrospective study of benign mesial temporal lobe epilepsy (bMTLE) between 1995 and 2014. METHODS: Hospital records and clinic charts were reviewed. The clinical, Eelectro...
Nov 28, 2016
Putignano D, Clavenna A, Campi R, Bortolotti A, Fortino I, Merlino L, Vignoli A, Canevini MP, Bonati M
PURPOSE: The aim of the study was to evaluate prescription profiles of antiepileptic drugs (AEDs) and to assess hospitalizations and specialist visits in pediatric patients with epilepsy. METHODS: The data sour...
Nov 27, 2016
Tanaka T, Yajima N, Kiyoshi T, Miura Y, Iwama S
Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models....

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