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Dec 17, 2014
Mittal M, Harrison DL, Miller MJ, Farmer KC, Thompson DM, Ng YT
OBJECTIVE: In January 2008, the Food and Drug Administration (FDA) communicated concerns and, in May 2009, issued a warning about an increased risk of suicidality for all antiepileptic drugs (AEDs). This research evalu...
Dec 17, 2014
Mintzer S, Maio V, Foley K
INTRODUCTION: The extent to which enzyme-inducing antiepileptic drugs (EIAEDs) are used as first-line treatment in the United States remains unknown. Studies suggest that EIAEDs produce elevation of serum lipids, which...
Dec 17, 2014
Ladino LD, Hernández-Ronquillo L, Téllez-Zenteno JF
OBJECTIVE: No consensus exists regarding the management of antiepileptic drugs (AEDs) after successful epilepsy surgery (ES). We performed a meta-analysis with the most relevant evidence in this topic. Our aim was to p...
Dec 17, 2014
Castilla-Puentes R, Ford L, Manera L, Kwarta RF, Ascher S, Li Q
PURPOSE: To evaluate fetal or neonatal outcomes (with a focus on major congenital anomalies) with use of topiramate monotherapy and to examine whether differences occurred in the reporting and patterns of these outcome...
Dec 17, 2014
Weber YG, Nies AT, Schwab M, Lerche H
The identification of valid biomarkers for outcome prediction of diseases and improvement of drug response, as well as avoidance of side effects is an emerging field of interest in medicine. The concept of individualiz...
Dec 17, 2014
Di Prospero NA, Gambale JJ, Pandina G, Ford L, Girgis S, Moyer JA, Xi L, Nye JS, Kasteleijn-Nolst Trenité D
PURPOSE: To evaluate the activity of JNJ-26489112 in patients with photosensitive epilepsy and determine the doses that result in reduction or complete suppression of the intermittent photic stimulation (IPS) induced p...
Dec 17, 2014
Wirrell EC, Wong-Kisiel LC, Nickels KC
OBJECTIVE: This study aimed to identify long-term seizure outcome in pediatric nonsyndromic focal epilepsy after failure of serial antiepileptic drugs (AEDs) due to lack of efficacy. METHODS: Children (1 month-...
Dec 17, 2014
Rizvi SA, Hernandez-Ronquillo L, Wu A, Téllez Zenteno JF
PURPOSE: Video electroencephalographic monitoring (VEM) is used to record ictal and interictal epileptiform activity and to ascertain the level of concordance between the two. Often, taper or discontinuation of anti-ep...
Dec 17, 2014
Fauser S, Essang C, Altenmüller DM, Staack AM, Steinhoff BJ, Strobl K, Bast T, Schubert-Bast S, Stephani U, Wiegand G, Prinz M, Brandt A, Zentner J, Schulze-Bonhage A
OBJECTIVE: Focal cortical dysplasia (FCD) is currently recognized as the most common cause of neocortical pharmacoresistant epilepsy. Epilepsy surgery has become an increasingly successful treatment option. Herein, the...
Dec 17, 2014
Chen B, Choi H, Hirsch LJ, Moeller J, Javed A, Kato K, Legge A, Buchsbaum R, Detyniecki K
OBJECTIVE: Cosmetic side effects (CSEs) such as weight gain and alopecia are common, undesirable effects associated with several AEDs. The objective of the study was to compare the CSE profiles in a large specialty pra...

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