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Oct 15, 2014
May TW, Pfäfflin M, Brandt C, Füratsch N, Schmitz B, Wandschneider B, Kretz R, Runge U, Geithner J, Karakizlis H, Rosenow F, Kerling F, Stefan H
OBJECTIVES: Due to demographic change and high incidence of epilepsy in elderly, the number of elderly with epilepsies is increasing. However, only few studies investigated the impact of epilepsy on quality of life (Qo...
Oct 15, 2014
Qiao X, Sun G, Clare JJ, Werkman TR, Wadman WJ
BACKGROUND AND PURPOSE: Voltage-activated Na(+) channels contain one distinct α-subunit. In the brain NaV 1.1, NaV 1.2, NaV 1.3 and NaV 1.6 are the four most abundantly expressed α-subunits. The antiepileptic drugs (AE...
Oct 15, 2014
Kverneland M, Taubøll E, Selmer KK, Iversen PO, Nakken KO
BACKGROUND: Modified Atkins diet is a treatment option for patients with pharmacoresistant epilepsy that is not suitable for surgery. In the last few years, we have tried dietary treatment added to antiepileptic drugs ...
Oct 13, 2014
Grosso S, Parisi P, Spalice A, Verrotti A, Balestri P
BACKGROUND: Lacosamide is effective and well-tolerated antiepileptic drug (AED) in both children and adults. AIM: This multicentric, prospective study investigates the efficacy and safety of lacosamide adjuncti...
Oct 10, 2014
Camfield P, Camfield C
Febrile seizures occur in ∼4% of children. After a first febrile seizure, the risk of recurrence is ∼40%, but excellent studies document that febrile seizures do not cause brain damage or deficits in cognition or behav...
Oct 10, 2014
Chen P, Yan Q, Xu H, Lu A, Zhao P
AIMS: The G1249A variant of the multidrug resistance-associated protein 2 (ABCC2) gene may be associated with the development of antiepileptic drug (AED) resistance. Although numerous studies have investigated the asso...
Oct 8, 2014
Zaccara G, Giovannelli F, Franco V, Cincotta M, Tramacere L, Verrotti A
BACKGROUND AND PURPOSE: Assessment of placebo and nocebo effects and evaluation of background incidence of some predefined adverse effects (AEs) of antiepileptic drugs (AEDs) in placebo-treated paediatric patients recr...
Oct 7, 2014
Boutros NN, Ghosh S, Khan A, Bowyer SM, Galloway MP
OBJECTIVES: Currently, there are no guidelines for when to use an antiepileptic drug (AED) in nonepileptic panic disorder (PD) patients. We conducted this review to ascertain what guidance available literature can prov...
Oct 6, 2014
Shazadi K, Petrovski S, Roten A, Miller H, Huggins RM, Brodie MJ, Pirmohamed M, Johnson MR, Marson AG, O'Brien TJ, Sills GJ
A multigenic classifier based on five single nucleotide polymorphisms (SNPs) was previously reported to predict treatment response in an Australian newly-diagnosed epilepsy cohort using a k-nearest neighbour (kNN) algo...
Oct 3, 2014
Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, Morrison PJ, Liggan B, Irwin B, Delanty N, Hunt SJ, Craig J, Morrow J
OBJECTIVES: Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK...