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May 26, 2015
Cramer JA, Wang ZJ, Chang E, Powers A, Copher R, Cherepanov D, Broder MS
OBJECTIVE: Epilepsy adversely affects childhood development, possibly leading to increased economic burden in pediatric populations. We compared annual healthcare utilization and costs between children (
May 26, 2015
Saengsuwan J, Laohasiriwong W, Boonyaleepan S, Sawanyawisuth K, Tiamkao S, Talkul A, Integrated Epilepsy Research Group
This cross-sectional study aimed to determine the number and types of falls and vehicular crashes with injuries , as well as some specific behavioral associations in people with epilepsy (PWE) in northeastern Thailand....
May 23, 2015
Suvichapanich S, Jittikoon J, Wichukchinda N, Kamchaisatian W, Visudtibhan A, Benjapopitak S, Nakornchai S, Manuyakorn W, Mahasirimongkol S
CYP2C9 is the key enzyme in aromatic antiepileptic drugs (AEDs) metabolism. CYP2C9*3 is a loss of function polymorphism. This study was designed to investigate genetic association between CYP2C9*3 and aromatic AED-indu...
May 23, 2015
Wang GX, Wang DW, Liu Y, Ma YH
Epilepsy is a serious neurological disorder that affects more than 60 million people worldwide. Intractable epilepsy (IE) refers to approximately 20-30% of epileptic patients that fail to achieve seizure control with a...
May 23, 2015
Gefroh-Grimes HA, Gidal BE
In neurological malignancies, antiepileptic drugs (AEDs) are frequently used to control the seizure activity that accompanies the disorder. There is a growing body of evidence on the importance of AED selection for rea...
May 23, 2015
Sun Y, Luo X, Yang K, Sun X, Li X, Zhang C, Ma S, Liu Y, Yin J
OBJECTIVE: Overexpression of ATP-binding cassette (ABC) transporters may contribute to intractable epilepsy (IE) by reducing brain accumulation of antiepileptic drugs (AEDs). We conducted a meta-analysis of studies on ...
May 20, 2015
May TW, Brandt C, Helmer R, Bien CG, Cawello W
OBJECTIVE: This study was carried out to estimate the exposure of the central nervous system (CNS) to the antiepileptic drug (AED) lacosamide, under steady state conditions, in patients with epilepsy who take oral laco...
May 20, 2015
Laurenza A, Yang H, Williams B, Zhou S, Ferry J
OBJECTIVE: The liver plays a major role in the metabolism and elimination of many antiepileptic drugs (AEDs), including perampanel. Some of the metabolites identified for perampanel are likely formed via reactive inter...
May 20, 2015
Vyas MV, Davidson BA, Escalaya L, Costella J, Saposnik G, Burneo JG
OBJECTIVE: To characterize the association between commonly used anti-epileptic drugs (AEDs) and plasma lipid levels in patients with epilepsy. METHODS: We sought observational studies that reported association...
May 17, 2015
Bates K
Although epilepsy has a prevalence of 5 to 7 per 1000 persons in the United States, it continues to be a poorly understood condition. Given the number of patients in the United States with epilepsy, it is very likely t...

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