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Aug 28, 2016
Toledo M, Gonzalez-Cuevas M, Miró-Lladó J, Molins-Albanell A, Falip M, Martinez AB, Fernandez S, Quintana M, Cambrodi R, Santamarina E, Salas-Puig J
PURPOSE: The purpose of this study was to evaluate subjective sleep quality and daytime sleepiness in patients receiving adjunctive perampanel for focal seizures. METHODS: We conducted a multicenter, prospectiv...
Aug 28, 2016
Bruun E, Kälviäinen R, Keränen T
PURPOSE: A study was carried out to assess the outcome of initial antiepileptic drug (AED) monotherapy in elderly patients with newly diagnosed epilepsy and to investigate the cumulative probabilities of ≥2- and ≥5-yea...
Aug 27, 2016
Meisel C, Plenz D, Schulze-Bonhage A, Reichmann H
Pathologic increases in excitability levels of cortical tissue commonly underlie the initiation and spread of seizure activity in patients with epilepsy. By reducing the excitability levels in neural tissue, antiepilep...
Aug 26, 2016
IJff DM, van Veenendaal TM, Debeij-van Hall MH, Jansen JF, de Louw AJ, Majoie MH, Aldenkamp AP
INTRODUCTION: Although ethosuximide is one of the oldest antiepileptic drugs (AEDs), little information is available about the cognitive side effects of ethosuximide. OBJECTIVE: The aim of this study was to inv...
Aug 25, 2016
Zhang Q, Yang F, Hu Z, Zhang Z, Xu Q, Dante M, Wu H, Li Z, Li Q, Li K, Lu G
OBJECTIVES: Our aim was to investigate regional difference in brain activities in response to antiepileptic drug (AED) medications in benign epilepsy with central-temporal spikes (BECTS) using resting-state functional ...
Aug 25, 2016
Shiek Ahmad B, O'Brien TJ, Gorelik A, Hill KD, Wark JD
Antiepileptic drug (AED) therapy is associated with decreased bone mineral density; however, the time course for this development is unclear. The aim of this study was to evaluate bone mineral changes during the initia...
Aug 24, 2016
Nizard M, Jost J, Tanamasoandro R, Andriambololona R, Megherbi M, Solofomalala GD, Marquet P, Preux PM, Ratsimbazafy V
PURPOSE: To determine the accessibility of treatment and the quality of antiepileptic drugs (AEDs) in the Haute Matsiatra district of Madagascar. METHODS: Cross-sectional descriptive study and interviews. Sampl...
Aug 24, 2016
Losch FP, Holtkamp M, McMurray R, Lendemans D, Kockelmann E
BACKGROUND: Due to inadequate seizure control achieved with antiepileptic drug (AED) monotherapy and the considerable side effects at high required doses, patients with partial-onset seizures (POS) often require AED co...
Aug 23, 2016
Shao Y, Wang C, Hong Z, Chen Y
It is widely recognized that P-glycoprotein (P-gp) mediates drug resistance in refractory epilepsy. However, the molecular mechanism underlying the up-regulation of P-gp expression remains unclear. Our previous studies...
Aug 23, 2016
Moreno Morales EY, Fernandez Peleteiro M, Bondy Peña EC, Domínguez Lorenzo JM, Pardellas Santiago E, Fernández A
BACKGROUND AND OBJECTIVES: Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy-rapid seizure termination-is only achieved in jus...

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