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Sep 21, 2017
Chen C, Chong YJ, Hie SL, Sultana R, Lee SHD, Chan WSD, Chan SY, Cheong HH
OBJECTIVE: Prior studies highlighted that patients on chronic medications who used complementary and alternative medicines (CAMs) did not share this information with their healthcare providers. Furthermore, there might...
Sep 21, 2017
de Toffol B, Kanemoto K
Psychosis in epilepsy can be categorized in relation to seizures in two main categories: interictal psychosis and postictal psychosis. Postictal psychosis (PIP) is a specific syndrome in relation to seizure activity: a...
Sep 21, 2017
Li Z, Fang L, Jiang W, Kim MJ, Zhao L
PURPOSE OF REVIEW: This review summarizes the current FDA practice in developing risk- and evidence-based product-specific bioequivalence guidances for antiepileptic drugs (AEDs). RECENT FINDINGS: FDA's product...
Sep 21, 2017
Nikanorova M, Brandt C, Auvin S, McMurray R
INTRODUCTION: Rufinamide is approved for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged ≥4years. The objective of this study was to provide real-world, long-term dat...
Sep 21, 2017
Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP, UAB CBD Program
OBJECTIVE: To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. ...
Sep 16, 2017
Lockney DT, Vaziri S, Walch F, Kubilis P, Neal D, Murad GJ, Rahman M
BACKGROUND: Prophylactic use of antiepileptic drugs (AEDs) for patients undergoing brain tumor surgery is common practice despite lack of clear evidence. We hypothesized that prophylactic AED (pAED) use did not affect ...
Sep 16, 2017
Iqbal M, Ezzeldin E, Al-Rashood KA
Brivaracetam (BVR) is a novel antiepileptic drug (AED), approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under t...
Sep 16, 2017
Theitler J, Brik A, Shaniv D, Berkovitch M, Gandelman-Marton R
INTRODUCTION: The use of antiepileptic drugs (AEDs) in older patients with epilepsy is challenged by polypharmacy and decreased drug elimination. Newer AEDs have a lower potential for drug interactions and are reported...
Sep 14, 2017
Modi AC, Junger KF, Mara CA, Kellermann T, Barrett L, Wagner J, Mucci GA, Bailey L, Almane D, Guilfoyle SM, Urso L, Hater B, Hustzi H, Smith G, Herrmann B, Perry MS, Zupanc M, Varni JW
OBJECTIVE: To validate a brief and reliable epilepsy-specific, health-related quality of life (HRQOL) measure in children with various seizure types, treatments, and demographic characteristics. METHODS: This n...
Sep 12, 2017
Gambardella A, Labate A, Mumoli L, Lopes-Cendes I, Cendes F
BACKGROUND: Growing evidence indicates that pharmacogenomics will positively impact treatment for patients with epilepsy in the near future, leading to the implementation of a precision-based use of antiepileptic drug ...