Diastat is generally well-tolerated.

  • The most common side effect reported during research studies was sleepiness. Since it is given after a seizure, it may be hard to tell if sleepiness is due to the seizure or the medicine.
  • Other but less frequent side effects include:
    • Dizziness, headache, pain, stomach pain, nervousness, dilated blood vessels, diarrhea, unsteady walking, clumsiness, euphoria or elevated mood, asthma or wheezing, stuffy nose, and skin rash.
  • If any of these side effects occur, talk to the doctor and nurse about what to do.
    • If your child develops a serious problem or has trouble tolerating it, you may be told not to give it to your child again.
    • If other minor side effects occur after using it, write down what happens and how your child feels in a seizure diary to share with the doctor.


  • Write down how your child feels after using Diastat.
  • Call the doctor or get emergency medical attention for your child if any serious problems occur after using Diastat.