The Epilepsy Foundation SUDEP Institute is awarding more than $1 million for a series of at least three prize challenge competitions that work to build awareness for, predict and prevent SUDEP. Learn more about the challenge series and register for the current challenge.
Below is a list of selected sudden unexpected death in epilepsy (SUDEP) articles featured on Epilepsy.com or published elsewhere.
"SUDEP Risk in Pediatric Epilepsy Syndromes," March 21, 2017, whether specific causes of epilepsy, such a genetic defect, may increase SUDEP risk beyond what is predicted by seizure severity and frequency.
"Post-ictal Physiology: Adding Blood Pressure to the Equation," December 21, 2016, reviews new studies of seizure-related blood pressure changes that improve understanding how tonic-clonic seizures can trigger deadly heart, brain, and breathing dysfunction in SUDEP and may provide a new target for intervention.
"Does a Seizure Always Occur in SUDEP?," October 5, 2016, a few recent cases where a person with epilepsy was undergoing video-EEG monitoring and died suddenly indicate that seizures may not be absolutely necessary in SUDEP.
"Epilepsy Foundation Launches Multi-channel Campaign Urging People Living with Seizures to #AimForZero SUDEP," September 15, 2016, press release about a new expert consensus report identifying four key actions to help reduce risk of seizures and save lives.
"A risk for Sudden Death in Epilepsy that Often Goes Unmentioned," August 22, 2016, New York Times article discussing the problems with lack of disclosure for the risks of SUDEP.
"Epilepsy Foundation Announces Final $1 Million Challenge to Identify Biomarkers Predicting SUDEP," August 10, 2016, press release on progress of SUDEP Challenge Initiative.
"Role of the Screening ECG in People with Epilepsy," June 14, 2016, looks at whether a routine screening, 12-lead electrocardiogram (ECG) could help identify people with epilepsy who are at risk for sudden cardiac death or myocardial infarction.
"Epilepsy Foundation SUDEP Institute Announces Winner for Second Challenge: 'EpSMon' Mobile App - Preventing Epilepsy Seizures," March 2, 2016, press release announcing challenge winners and the next challenge.
"The Search for Genetic Risk Factors for SUDEP," February 22, 2016, reviews the study of genetic risk factors for SUDEP and what we have learned.
"SUDEP and Pregnancy," December 2, 2015, discusses the risk of SUDEP during pregnancy.
"An Update from the Center for SUDEP Research," November 15, 2015, provides information about the Center for SUDEP Research and what its researchers are doing.
"SUDEP and the Gene DEPDC5," November 15, 2015, explains the recent research finding between Gene DEPDC5 and SUDEP as well as genetics and epilepsy.
"Breathing Problems and SUDEP," September 15, 2015, summarizes a study by Brian Dlouhy MD and colleagues on how breathing is effected. Seizure-related respiratory dysfunction may play a critical role in the pathophysiology of SUDEP.
"SUDEP Mechanisms," July 20, 2015, summarizes recent research into how seizures can lead to heart and breathing failures that may cause SUDEP. This research may lead to new avenues for preventing SUDEP.
"Iowa researchers gain important insight into sudden unexpected death in epilepsy," July 16, 2015, explains how by using electrical stimulation to activate the amygdala, a group of University of Iowa researchers identified areas of the human brain in which breathing is controlled and, in some cases, impaired, providing an important insight into SUDEP.
"Epilepsy Foundation SUDEP Institute Offering More Than $1 Million in Prize Money for Challenge Winners," June 11, 2015, press release about three prize challenges aimed to demystify seizures, empower People with epilepsy, and prevent SUDEP.
"Inflammation and SUDEP," April 29, 2015, about the role of brain inflammation in cardiovascular consequences of seizures and its implications for SUDEP.
"What is the Role of Body Position in SUDEP?, March 4, 2015, about how body position while sleeping may influence the risk of SUDEP and steps you can take to minimize your risk.
"The Relationship between Epilepsy and Premature Death in Children," February 4, 2015, reviews several studies that have found children with epilepsy have a higher mortality rate. The causes of death and contributing conditions are less well understood.
"The Holidays are Over, Now Let's Unwrap our Grief," January 13, 2015, offers some advice on how to handle grief after the holidays in a healthy manner.
"Coping with Holiday Grief," December 2, 2014, an Epilepsy Foundation SUDEP Institute grief therapist shares some words of advice to help cope during the holiday season.
"SUDEP Awareness," November 19, 2014, covers how often people with epilepsy are made aware of the risk of sudden unexpected death in epilepsy and how they are finding out about SUDEP.
"Upcoming Holidays: A Time for Cheers or Tears," November 5, 2014, an Epilepsy Foundation SUDEP Institute Grief Therapist shares some words of advice to help navigate the upcoming holiday season, especially if you have lost someone to seizures.
"Expanding the Types of Genetic Mutations Involved in Shared Mechanisms of Epilepsy and Sudden Death," October 30, 2014, a mouse study adds to the growing body of evidence showing that more gene mutations could be contributing to seizure and SUDEP risk.
"Estimating the Incidence and Public Health Burden of SUDEP," October 1, 2014, Epilepsy.com SUDEP editor Dr. Dan Friedman looks at how accurate estimates are for SUDEP rates and how researchers arrive at those numbers.
"SUDEP Basic Science,"S eptember 17, 2014, a summary of the Partners Against Mortality in Epilepsy Conference that focuses on the current research on potential causes of mortality in people with epilepsy, including respiratory issues, sleep, cardiac failure, and genetics.
"Help for Families who have Lost Someone with Seizures," July 24, 2014, find out what help is available for people who have lost a loved one, and how you can get involved.
"Using Special Pillows to Potentially Prevent SUDEP," July 9, 2014, summarizes a study that examined whether “anti-suffocation” pillows could theoretically prevent the build up of dangerous levels of carbon dioxide as a way to reduce SUDEP risk.
"Epilepsy-related Deaths During Pregnancy," May 28, 2014, some epidemiological studies have suggested an increased risk of death during pregnancy among women with epilepsy compared to women without epilepsy.
"SUDEP and Genetics," May 7, 2014, much of the research into the genetic risks of sudden unexpected death in epilepsy has focused on single gene mutations that give rise to risks for mortality. However, a recent study may move us beyond a search for a single gene as the cause.
"SUDEP and the Burden of Sudden Death in the Young," April 23, 2014, learn about the huge growth in available information about SUDEP.
"One Family’s Loss Spurs SUDEP Awareness," February 19, 2014, read about how a grieving family is working to help others with epilepsy.
"How Do You Learn About SUDEP?," February 12, 2014, learn about the huge growth in available information about SUDEP.
"SUDEP Surveillance?," January 15, 2014, SUDEP Editor Dr. Daniel Friedman looks at efforts to fully understand SUDEP.
"Seizures Can Stop The Heartbeat: Does This Cause SUDEP?," January 8, 2014, Dr. Gena Ghearing explores this connection and calls for more study.
"SUDEP: The Need for Global Conversation," November 21, 2013, learn about the need for increased awareness and discussion about SUDEP.;
"Could Oxygen Starvation of the Brain Cause SUDEP?," September 11, 2013, learn about this potential cause of SUDEP.
"Making Progress to Build Awareness for SUDEP," September 4, 2013, the SUDEP Institute has made a lot of progress since being launched by the Epilepsy Foundation six months ago. Find out more about the current work of the Institute and future plans.
"Electric Shutdown of the Brain: is it a cause of SUDEP?," July 17, 2013, learn about electric shutdown of the brain, and if it is a cause of sudden unexplained death in epilepsy.
"Why is Animal Research Important in SUDEP?," June 12, 2013, Carl L. Faingold, PhD, looks at animal models of SUDEP that are vital to developing treatments
"Talking about SUDEP, May 15, 2013, Patty Osborne Shafer RN, MN, looks at discussing the risk of SUDEP.
"The SUDEP Institute: What Is It? Why is it Needed?," May 8, 2013, Elson L. So, MD, from the Mayo Clinic - Minnesota, looks at the SUDEP Institute, a big step forward in the fight against SUDEP.
"Prevention of SUDEP," August 8, 2012, Dr. Orrin Devinsky talks about SUDEP prevention.
"Predicting Sudden Death from Epilepsy," May 30, 2012, Joseph Sirven, MD, epilepsy.com editor-in-chief, presents a study looking at the effectiveness of using monitoring devices in predicting SUDEP.
"Sudden Unexpected Death in Epilepsy: Risk Factors," March 2012, in the February 2012 issue of the journal Epilepsia, there are two studies that address the risk factors of SUDEP. Both studies are important additions to our understanding of the issue of death and epilepsy.
Friedman D, Hirsh L Sudden Unexpected Death in Epilepsy, An Overview of Current Understanding and Future Perspectives. European Neurological Review, 2012;7(1):67-71.
"Sudden, Unexpected Death in Epilepsy," Dr. Orrin Devinsky
"Adjunctive Anti-epileptic Drug Therapy and Prevention of SUDEP," October 2011, a meta-analysis of the impact of anti-epileptic drugs on the prevention of SUDEP.
"Recently Published Results of U.S. Government-Sponsored Workshop on SUDEP," July 2011, momentum against SUDEP results from a continuing effort by the scientific and the lay communities in finding ways to expand research and education in SUDEP.
"Who is at risk for SUDEP," July 2011, this research helps to further our knowledge of identifying individuals early who may be at risk for sudden death from seizures.
"SUDEP Recommendations," May 2011, essential reading for all professionals who deal with epilepsy. Find the blueprint for future trials, collaborations and education of both professionals and people living with epilepsy and their caregivers.
"New Campaign to Shed Light on Epilepsy's Dark Secret," May 13, 2011, press release about the launch of a SUDEP awareness campaign.
"Building the Momentum Against SUDEP," April 2011, there is clearly a mounting momentum against SUDEP in the last few years, which is urgently needed to address the many research, education, and counseling issues in SUDEP.
"High SUDEP Rate in Some Persons with Childhood-Onset Epilepsy," January 2011, a commentary by Elson L. So, MD. The cause of SUDEP is still unknown, but Drs. Sillanpää and Shinnar's study reinforces the need to strive for seizure control as one current strategy for reducing SUDEP in persons with epilepsy.
"SUDEP A Global Conversation," 2005 book from Epilepsy Australia. Reprinted with the permission of Epilepsy Australia - the national coalition of Australian epilepsy associations and Epilepsy Bereaved UK.
"Combined Analysis of Risk Factors for SUDEP," Hesdorffer, D., T. Tomson, et al.
"SUDEP, VNS and the FDA," November 2010, in a recent issue of the British Medical Journal, two journalists criticized the U.S. Federal Drug Administration on its lax oversight of safety of approved medical devices.
"Unmasking Silent Killer in Epilepsy, July 2010, New York Times article. Steve Wulchin discusses SUDEP, "There's no magic answer, but awareness."
"A Preventable Cause of SUDEP Finally is Established," March 2010, Baylor researchers find a gene linking heart irregularities with epilepsy, giving an important clue to the mechanism sudden unexpected death in epilepsy.
Articles Before 2010
"Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms," Surges R, Thijs R, Tan H, Sander J.
"Sudden unexpected death in epilepsy: current knowledge and future directions," Torbjörn T, Nashef L, Ryvlin P.
"Sudden unexplained death in epilepsy: observations from a large clinical development program," Leestma JE, Annegers JF, Brodie MJ, et al.