Keppra generics, change in manufacturers

Newbie here, first post.  I am a parent of a daughter who is a college freshman away from home.  She takes 1000 mg generic Keppra 2x day to control seizures (tonic-clonic, absence, partial complex) that started 7 years ago when she was 11 (cause of seizures is unknown).  We have to get our long-term prescriptions from Medco, and the generic Keppra she has taken for the past 18 months has been manufactured by Teva.  Medco has just switched manufacturers to Torrent.

Has anyone had any issues with generic Keppra manufactured by Torrent?  We can't be the only ones who have to use Medco.  My daughter has about 20 days left of the Keppra manufactured by Teva, then she will have to switch over.  The switch will happen after her midterms, so she has that going for her. 

Thank you in advance for any input.


Re: Keppra generics, change in manufacturers

I too have Medco and refilled my Rx this week and realized that the pills didn't look the same. I checked the manufacturer and it was Torrent. I was taking the Teva generic before today. I've got an appointment with my neurologist today, and I plan on bringing it up. A friend of mine who is a pharmacist said as long as the "Inert/inactive" ingredients stay consistent it would not be a problem. I have had problems before with generics not acting the same, so I become very leery when things change.

Hopefully, I'll have something to post after my appointment. BTW... I was looking for the same info you were about the generics and came across this website, so I'm a newbie too. Looks like there's a lot of info on here.

Will let you know what the "doc" says!


p.s. Been dealing with seizures since I was 8... I'm now in the 40 somethings =)

Re: Keppra generics, change in manufacturers

Hi! I know it's been a while since these were posted and I hope everything has worked out for everyone. I came across these posts while researching the Teva form of Keppra. I had Medco last year for my generic Lamictal (lamotrigine). It was like pulling teeth to get a regular supply of pills from them. "Worry free refills" my foot! Eventually I ended up at Sam's Club for their lamotrigine by Teva. Because lamotrigine isn't working, my doc is switching me to Keppra. Sam's Club's generic Keppra is by Teva also. Did you notice any differences between Teva and Torrent?

Re: Keppra generics, change in manufacturers

Hi, finally got my password figured out.  Your post caught my attention, my daughter was taking Lamictal for several months.  Her neurologist kept increasing the dosage, but she was having seizures (sort of ran the whole spectrum, we never knew which one she'd get) every eight days, right on the date, but we wouldn't know the hour.  She could plan her schedule based on her seizures. 

We complained that taking Lamictal was like taking no meds at all, and we were proven correct.  My daughter was sent to an epilepsy monitoring unit, and there exists over 400 hours of monitoring data that prove Lamictal was ineffective for controlling her seizures.  (That's 17 days, by the way.  The neurologists never did figure out where in the brain her seizures originate.  They gave up looking and placed her on Keppra.)  

I hope Keppra is working for you.  It gave my daughter the chance to leave home for college & hold down a job, although she doesn't drive.  In my other post tonight, I mentioned about side effects we have noted.   

No differences in the generic Keppra from Teva or Torrent, according to my kid.

Re: Keppra generics, change in manufacturers

Since september 2011 I have been given 4 different manufacturers of Levetiracetam.  Mylan,Teva, Solco and Torrent, currently torrent.  Since that time I have had 4 gan mal seizures starting in December of 2011.  I researched the shipping dates and manufacturer time frame vs the seizures, all were within about a month apart.  each time the docters kept raisng my dose.  Finally to 6000mg/day( Iknow unbelievable.).    I am weaning off of the drug now and will be going back to Dilantin.  I only had problems  with that when the dose was lowered.        Could be a coincidence and age may be a factor.  BUT...  I have had as many seizures in 11 monthes than I have had since 1993 to 2011.   I had febrile seizures as an infant, then at age 34 , I am now 55.

I also have a list of all inactive ingredients for each manufacturer

Also anyone having urinary tract issues with levetiracetam.


Re: Keppra generics, change in manufacturers

Hi, I am the originator of this thread, finally got a new password and a few minutes to post a reply.

My daughter did not find any difference between Keppra manufactured by Teva or Torrence, both generics worked equally well, in her opinion.

My daughter's meds were tweaked in April, she currently takes 1000 mg in the am and 1250 mg in the pm, the 250 mg were added this spring.  She has had the life of a normal teen since then, we'll take it.  She heads back for her second year at college this week.  This is the third drug she has taken, she has also used Topamax and Lamictal.  Topamax stopped working after four years, Lamictal was equal to taking no meds at all (NO effect on stopping seizures), and she has taken Keppra since April 2010.

She does take a vitamin B6 tablet (a small one, 50 mg?), on days when she expects stress.  She says it helps controlling emotions during high-stress situations.  One side effect seems to be thinner hair, she has switched to a very soft brush which is helping a bit.

Re: Keppra generics, change in manufacturers

Hey everyone...hope you are well! Just a thought from a Mom who has a daughter who has failed 3 med trials and is presently on Keppra 4500mg a day. In February we started her on a supervised ketogenic diet and she has not had a seizure in 182 days. She was having absense seizures 2 to 3 times a day before that while on Keppra and zonagram. I never go with the generic as I don't trust changing manufacturers. But since becoming a Keto kid we have reduced her meds by 1000mg and after our next clear eeg (we had our first in June) she will be reduced again. Ketogenic diet is a miracle come true and if any of you are interested I would be willing to discuss it with you. Take care, Tara

Re: Keppra generics, change in manufacturers

Excipients ,aka Inert ingredients , are NOT INERT

Recently, I took a generic of  Keppra that worked well for 7 years. The brand-name also costs 5000 Dollars a year. The generic,which costs 320 a year,   meant unbearable itching and burning, but good control. My problem was probably one or more of the "Inert" ingredients also known as the fillers or excipients .
From the web, I found:
"The excipients and additives in drug formulations have been described as inert because they do not have an active role in the prevention or treatment of particular ailments. This has led to the misconception among physicians, pharmacists, drug manufacturers and the public that excipients are harmless and unworthy of mention. In fact, pharmacists are allowed to substitute drug formulations, without regard to the excipients, as long as they ensure that the active ingredients in the substitute are the same as those in the formulation prescribed.
The inappropriateness of the term inert is becoming increasingly apparent as evidence of adverse reactions--some fatal--to excipients mounts. The likelihood that some "active" constituents have been blamed for such reactions deserves to be investigated. The public deserves to be better protected. For example, the United States has legislation requiring complete labelling of all food, drugs and cosmetics that incorporate more than one ingredient, no matter how innocuous the constituents are believed to be. "

With the help of a smart local pharmacist, and after trying three generics, I may have found the Culprit "Inert" Excipient. Unlike mail-order or chain pharmacies, which are both luck of that month's draw, he will keep me on the same company's formulation.

Re: Keppra generics, change in manufacturers

It's so nice to hear other people say they don 't trust the generics of certain medications.  We are having serious insurance issues with Zarontin. My son has been taking the brand name for years for absence seizures and we recently changed insurance companies and we may have to switch to the generic.  He is 42 and disabled with very little seizure control so I hesitate to change one med that is working.  Any input would be welcome.