I have been on Keppra for a few years, and experienced the not-so-uncommon increased anxiety and depression. I recently read an anecdotal report about vitamin B6 deficiency occuring with some patients on Keppra. Does anyone have a citation for the paper that reports this? I can't seem to find it on pub med or medline. Anyone here on Keppra had a vitamin B6 blood level checked that came back low/deficient?
I began a trial of 100 mg Vitamin B6 about 2 weeks ago, and feel significantly better (mood). It's really amazing, but I'm tempted to discontinue and see if my signs of depression/anxiety return. If they do- maybe check a vitamin B6 blood level to see if I'm truly deficient on Keppra.
I'd be curious to hear others experience with treating keppra mood side effects with vitamin B6.