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Adderall XR and Seizure medications

I just went to see my doctor for my check - up and I told her of some symtoms that I have been having for a while now and she put me on the very small dose of Adderall XR, which is 5mg. I was wondering if anyone else is taking Adderall or Adderall XR with their seizure meds. I am already taking Lamictal, Keppra XR, and Klonopin. One of the side effects of this medication is possible seizures, but it is very rare. I was just wondering what others thought too.


I too am on several medications to control my seizures (Keppra, Neurontin, Diamox Sequals) and I am on adderall. I take the regular adderall just in case I start having a really bad seizure day, this way the drug is shorter in my system and will be out in a few hours compared to the 12hrs for the XR.  I take 5mg in am and 5 mg around lunch if needed. Dr says that the seizure threshold is less when take the adderall, that's why chose this route.

My doctor informed me that stimulant medications can increase the seizure threshold but it's very dependent on the person. I have been prescribed Adderall XR 30mg for about five years now for ADHD and was diagnosed with epilepsy (CP with secondary generalizations) in July 2010. According to my GP and neurologist, it is highly unlikely that the stimulants caused the TC seizures so I continue to take Adderall XR with my AEDs (currently weaning off Keppra and adding Lamictal). Unless you are very sensitive to stimulant meds then I wouldn't be too concerned about the Adderall XR. You are also on a very small dose, which is a good thing. Best of luck to you.

If a person has some type of epilepsy, the stimulants - alerting agents (examples: coffee, caffeine compounds, Ritalin, Dexedrine, Adderall and so on) can lower the seizure threshold/change how epilepsy medicines work. That's my understanding. Classic epilepsy and classic ADHD / ADD / Hyperactivity / attention deficit(s) are different.

Hi Jamie,

 You didn't indicate the symptoms you were having or the dosage of seizure meds you were taking so I'm not sure why your physician prescribed the Adderall.  In my daughter's case she was and still is taking 5000 mg. of Keppra(along with all her other seizure meds) which caused her to have extreme fatigue.  At the time she was pursuing her bachelor's degree and could hardly make it through the day.  Her doctor prescribed 20 mg. Adderall XR for her to be able to concentrate and keep from being so tired.  She chose to take it only during the week to keep from getting addicted as well as having it lose it's potency.   Of course, on the weekends without the Adderall she felt like a zombie she was so tired. 

I realize I'm a little late to the party but I just ran across this thread. I can relate to bamamom since I'm in a similar situation. AEDs affect my energy level and my corrective surgeries have affected my attention span.

My epileptologist suggested testing with a neuropsychologist, who concluded that I may not have grown up with ADD, but I have all the symptoms now. Neuro started me on 10 mg Adderall as a conservative start, then bumped me to 20mg XR. I've stayed at that dose but my neuro also added 10mg IR to supplement midway through the day since I'm metabolizing it quickly. Only three months so far but no issues yet. I see your post is from awhile ago so you've probably made your decision, but for any others making this decision take note that while seizures may be rare in general for this drug, they aren't as rare for people with epilepsy. That said, your neuro should be able to put you at a dose that works while still taking into account your condition.


Takehisbrain (but not all of it)
4k mg Keppra
500 mg Dilantin
1k mg Lamictal
2 partial right frontal lobectomies
1 temporal resection

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