My son is 18 years old he has boderline Lennox Gastaut Syndrome, moderate learning difficulties and Aspergers syndrome.
Until four months ago he was having hundreds of seizures weekly usually 20 second tonic seizures with 3-4 minute break between each and mostly at night. His current medication is lamotrigine and epilim, he has been on this for several years.
Although lamotrigine didnt stop the seizures, my son started having auras and so there is less risk of an accident as he has 30 seconds warning to get safe. Lamotrigine is a powerful glutamate blocker, glutamate being the most abundant excitatory neurotransmitter in the brain it binds to aspartate and causes over excitation leading to a seizure so it made sense to me to carry on blocking it even though it didnt give us seizure control.
The next step was to raise GABA which is the job of epilim in this equation, GABA being the most important inhibitor of excessive firing in the brain leading to a seizure. Although we did see some improvement this didnt stop the seizures either but again it made sense to me to carry on raising GABA. The next step was to research dietary glutamate and in particular monosodium glutamate. The FDA and FSA official line is that it is safe to consume but in their own research they state that MSG can cause seizures in people who are sensitive to it, it is widely thought that it can not cross the blood brain barrier which filters it out before it reaches the brain but in people with epilepsy the BBB is more permeable and does let it though and it was and is a major trigger of my sons seizures. At this stage though a massive improvement still not seizure freedom so I started looking into how vitamins, minerals and amino acids were effected by glutamate and which play a protective roll in the brain, I soon found out that magnesium, B6 and the amino acid taurine all have protective rolls in the brain and that they were things that we could get in our diets which actually effect the brain. Even though I use magnesium at times when he is more prone to seizures; late medication,after vomiting, temperature and times of stress I dont supplement it daily as I dont think he has a problem utilizing it. I give B6 after I suspect MSG consumption but again dont use it regularly, but do recommend that it is tried. The missing ingredient that has lead to my sons seizure freedom is taurine it plays so many important roles in the brain, in all people with epilepsy taurine levels are significantly lower it is extremely sensitive to MSG and needs to be supplemented.
If you would like to know more about taurine I have a face book group;
Treatment for Epilepsy - Taurine & Adjunctive Therapies
I would love to hear from anyone who is interested, thanks for your time I hope you have found this helpful.