Epilepsy Phenome/Genome Project
The Epilepsy Phenome/Genome Project (EPGP) is the largest study ever created to understand how genetics influences epilepsy. Researchers from major epilepsy centers around the United States have collected blood samples and detailed seizure histories on a group of people with specific types of epilepsy. This information will be used to identify genes that contribute to a person developing epilepsy and the response to seizure medications. The hope is that this information will reveal new insights and improve diagnosis and treatment, and answer the troubling questions described above.
To understand the complex genetics of epilepsy, researchers enrolled people with epilepsy (not due to a known reason like stroke, head injury, or brain infection) who also have a brother, sister, parent, or child with epilepsy. The study also enrolled participants who have seizures due to Infantile Spasms, Lennox-Gastaut Syndrome, polymicrogyria, or periventricular heterotopias. Although the results of the study will apply to many different people with epilepsy, focusing this research effort on very specific types of epilepsy will allow the genetic analysis to be completed faster.
This study is funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke.