The AES and the Epilepsy Foundation are partnering to provide an opportunity for scientists to obtain support for nationwide or international networks of clinical or basic science researchers focused on understanding the causes, consequences and treatment of epilepsy. Multicenter research programs are viewed as an important venue through which investigators from around the world can establish centralized databases, common protocols, shared resources, core laboratories and exchange rapidly developing techniques and technologies. Such cooperative efforts are anticipated to hasten the speed of discovery. These funds are meant to be used to support pilot projects and hold organizational and planning sessions with representatives from each center in the planned network. These planning sessions should also be used to develop the research effort and collect results that would be used to prepare and submit a larger application for support from the Federal Government and establish the multicenter research program over the long term.

The Epilepsy Foundation partners with the American Epilepsy Society to support clinical and laboratory research networks focused on the causes, consequences, and treatment of epilepsy. Research Infrastructure Awards support pilot projects and planning sessions with representatives from each center in the planned network. Grants funded this cycle include:

  • Rational Intervention for KCNQ2 Epileptic Encephalopathy (RIKEE) network;
  • Pediatric Status Epilepticus Research Group (pSERG);
  • Establishment of a Multicenter Pediatric Epilepsy Group (PEG) to Facilitate Collaborative Research in Epileptic Encephalopathies of Infancy and Childhood.

Rational Intervention for KCNQ2 Epileptic Encephalopathy (RIKEE) network

Edward Cooper, M.D., Ph.D
Associate Professor of Neurology and Neuroscience
Baylor College of Medicine
Houston, TX, United States

Pediatric Status Epilepticus Research Group (pSERG)

Tobias Loddenkemper
Children's Hospital Boston
Boston, MA, United States

Establishment of a Multicenter Pediatric Epilepsy Group (PEG) to Facilitate Collaborative Research in Epileptic Encephalopathies of Infancy and Childhood

Elaine Wirrell, M.D. - Mayo Clinic Rochester
Kelly Knupp, M.D.- University of Colorado

This project seeks to establish a functional, multicenter network of U.S. pediatric epileptologists to further study causes, best treatments, and outcomes of epileptic encephalopathies in infants and children.  Epileptic encephalopathies are among the most severe childhood brain disorders, and include many of the rare epilepsies, including Dravet syndrome; Landau-Kleffner syndrome; Lennox-Gastaut syndrome; and West syndrome.   Intractable seizures and extreme cognitive deficits are frequent symptoms, and often progress relentlessly to early death. Grant recipients also propose to demonstrate that the PEG  network can collaborate effectively in clinical research.

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